Neuropathy is the disturbance of function or pathological change in a nerve.
Charcot- Marie-Tooth (CMT) disease, named for three physicians who first identified the disease in 1886, is usually inherited as a dominant trait and is the most common disease within a group of conditions called Hereditary Motor and Sensory Neuropathies (HMSN).
CMT affects approximately 125,000 individuals in the
There are thought to be at least five genetic causes of CMT that lead to two distinct types of nerve disease. HMSN Type 1 where there is damage to the nerve fiber insulation and HMSN Type 2 where there is damage to the nerve itself.
The disease is marked by a slow progressive muscle weakness in the feet lower legs, hands and forearms and a mild loss of sensation in the toes, feet and fingers.
Diabetics with advanced neuropathy are unable to detect when too much pressure is being placed on a bony prominence of the foot. As a result there is a break or hole in the skin, known as an ulcer, and the diabetic can not feel this pain. The most common ulcerations occur on the sole or plantar surface of the foot and the metatarsal heads and hallux. Of the 15% of diabetics that will experience diabetic foot ulcers, as many as 20% of these diabetics will suffer from lower extremity amputation.
Accommodative, seamless, soft, stretch footwear with a hook and loop closure, together with a removable insole for custom inserts are often recommended by footwear professionals.
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